Everolimus is the 40-O- derivative of sirolimus and works similarly to sirolimus as an inhibitor of mammalian target of rapamycin. It is currently used as an immunosuppressant to prevent rejection of organ transplants and in the treatment of renal cell.

Gefitinib is a drug used for certain breast, lung and other cancers. Gefitinib is an EGFR inhibitor, like erlotinib, which interrupts signaling through the epidermal growth factor receptor in target cells. it is only effective in cancers with mutated.

Cabozantinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply.

Palbociclib is a targeted therapy Known as CDK416 inhibitor. Palbociclib is indicated for the treatment of hormone receptor (HR) positive, human epidermal growth factor receptor 2(HER2)-negative locally advanced or metastatic breast cancer.